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1

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ohsawa, Ikuroh, Ishikawa, Masahiro, Takahashi, Kumiko, Watanabe, Megumi, Nishimaki, Kiyomi, Yamagata, Kumi, Katsura, Ken-ichiro, Katayama, Yasuo, Asoh, Sadamitsu, Ohta, Shigeo

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 622 KB

english, 2007

2

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

Naomi Kamimura, Kiyomi Nishimaki, Ikuroh Ohsawa, Shigeo Ohta

Journal:

Year:

2011

Language:

english

File:

PDF, 2.33 MB

english, 2011

3

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Nagata, Kazufumi, Nakashima-Kamimura, Naomi, Mikami, Toshio, Ohsawa, Ikuroh, Ohta, Shigeo

Journal:

Neuropsychopharmacology

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

4

P2-451: Hydrogen acts as a therapeutic antioxidant in brain ischemia and restores learning and memory deficits declined by physical restraint stress

Ohsawa, Ikuroh, Nagata, Kazufumi, Takahashi, Kumiko, Ishikawa, Masahiro, Mikami, Toshio, Ohta, Shigeo

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 54 KB

english, 2008

5

Consumption of hydrogen water prevents age-dependent memory impairment accompanying neurodegeneration in Alzheimer's model mice

Ohsawa, Ikuroh, Nishimaki, Kiyomi, Murakoshi, Norie, Yokota, Takashi, Ohta, Shigeo

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 100 KB

english, 2011

6

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

Nishimaki, Kiyomi, Asada, Takashi, Ohsawa, Ikuroh, Nakajima, Etsuko, Ikejima, Chiaki, Yokota, Takashi, Kamimura, Naomi, Ohta, Shigeo

Journal:

Current Alzheimer Research

Year:

2018

Language:

english

File:

PDF, 2.85 MB

english, 2018

7

Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress

Alexander M. Wolf, Sadamitsu Asoh, Hidenori Hiranuma, Ikuroh Ohsawa, Kumiko Iio, Akira Satou, Masaharu Ishikura, Shigeo Ohta

Journal:

The Journal of Nutritional Biochemistry

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

8

Consumption of Hydrogen Water Prevents the Age-dependent Impairment in Learning and Memory Tasks in AD Model Mice

Ohsawa, Ikuroh, Nishimaki, Kiyomi, Murakoshi, Hiroe, Yokota, Takashi, Ohta, Shigeo

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

9

P4-247 Deficiency in a mitochondrial aldehyde dehydrogenase promotes oxidative stress and the onset of Alzheimer's disease

Ohsawa, Ikuroh, Nishimaki, Kiyomi, Nukina, Takeshi, Ohta, Shigeo

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

10

S10.4 Mild uncoupling reduces oxidative stress in intact cells

Alexander M. Wolf, Sadamitsu Asoh, Ikuroh Ohsawa, Shigeo Ohta

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2008

Language:

english

File:

PDF, 69 KB

english, 2008

11

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress

Kei-ichi Fukuda, Sadamitsu Asoh, Masahiro Ishikawa, Yasuhiro Yamamoto, Ikuroh Ohsawa, Shigeo Ohta

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 1.93 MB

english, 2007

12

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury

Kentaro Hayashida, Motoaki Sano, Ikuroh Ohsawa, Ken Shinmura, Kayoko Tamaki, Kensuke Kimura, Jin Endo, Takaharu Katayama, Akio Kawamura, Shun Kohsaka, Shinji Makino, Shigeo Ohta, Satoshi Ogawa, Keiich

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 667 KB

english, 2008

13

Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice

Yuya Nakashima, Ikuroh Ohsawa, Fumiko Konishi, Takashi Hasegawa, Shoichiro Kumamoto, Yoshihiko Suzuki, Shigeo Ohta

Journal:

Neuroscience Letters

Year:

2009

Language:

english

File:

PDF, 832 KB

english, 2009

14

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

Ikuroh Ohsawa, Kiyomi Nishimaki, Kumi Yamagata, Masahiro Ishikawa, Shigeo Ohta

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 333 KB

english, 2008

15

Mitochondrial ALDH2 Deficiency as an Oxidative Stress

SHIGEO OHTA, IKUROH OHSAWA, KOUZIN KAMINO, FUJIKO Ando, HIROSHI SHIMOKATA

Journal:

Annals of the New York Academy of Sciences

Year:

2004

Language:

english

File:

PDF, 4.38 MB

english, 2004

16

Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese

Yoshihiko Suzuki, Fujiko Ando, Ikuroh Ohsawa, Hiroshi Shimokata, Shigeo Ohta

Journal:

Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 269 KB

english, 2006

17

Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis

Hoshi, Hiroko, Monoe, Fuka, Ohsawa, Ikuroh, Ohta, Shigeo, Miyamoto, Takeshi

Journal:

Biochemical and Biophysical Research Communications

Year:

2020

File:

PDF, 930 KB

2020

18

Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 570 KB

english, 2009

19

P3-365

Ohsawa, Ikuroh, Nishimaki, Kiyomi, Murakami, Yayoi, Suzuki, Yuko, Ishikawa, Masahiro, Ohta, Shigeo

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 572 KB

english, 2006

20

The response of left ventricular regional function to afterload stress in patients with old myocardial infarction and ventricular aneurysm.

MIYAWAKI, HIROSHI, TSUIKI, KAI, YAMAGUCHI, SEIJI, OHTA, IKUROH, SUKEKAWA, HIROYASU, IKEDA, HIDEKI, YASUI, SHOJI

Journal:

Japanese Circulation Journal

Year:

1991

File:

PDF, 1.15 MB

1991

21

Imaging Mitochondrial Redox Environment and Oxidative Stress Using a Redox-Sensitive Fluorescent Protein

Wolf, Alexander M., Asoh, Sadamitsu, Ohsawa, Ikuroh, Ohta, Shigeo

Journal:

Journal of Nippon Medical School

Year:

2008

Language:

english

File:

PDF, 535 KB

english, 2008

22

Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females

Ikuroh Ohsawa, Kouzin Kamino, Keiko Nagasaka, Fujiko Ando, Naoakira Niino, Hiroshi Shimokata, Shigeo Ohta

Journal:

Journal of Human Genetics

Year:

2003

Language:

english

File:

PDF, 207 KB

english, 2003

23

Obituary

Ohsawa, Ikuroh, Nishimaki, Kiyomi, Murakami, Yayoi, Suzuki, Yuko, Ishikawa, Masahiro, Ohta, Shigeo

Journal:

Year:

1972

Language:

english

File:

PDF, 146 KB

english, 1972

24

Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde

Yayoi Murakami, Ikuroh Ohsawa, Tadashi Kasahara, Shigeo Ohta

Journal:

Neurobiology of Aging

Year:

2009

Language:

english

File:

PDF, 505 KB

english, 2009

25

Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins

Toshiyuki Aokage, Ikuroh Ohsawa, Shigeo Ohta

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 1.04 MB

english, 2004

26

Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory

Sanae Nakajima, Ikuroh Ohsawa, Kazufumi Nagata, Shigeo Ohta, Makoto Ohno, Tetsuo Ijichi, Toshio Mikami

Journal:

Behavioural Brain Research

Year:

2009

Language:

english

File:

PDF, 1.03 MB

english, 2009

27

Continuous culture of novel mitochondrial cells lacking nuclei

Kazutoshi Nakano, Ikuroh Ohsawa, Kumi Yamagata, Tomohiro Nakayama, Kaori Sasaki, Mikako Tarashima, Kayoko Saito, Makiko Osawa, Shigeo Ohta

Journal:

Year:

2003

Language:

english

File:

PDF, 578 KB

english, 2003

28

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease

Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, Yumi Suzuki, Satoshi Maesawa, Yasukazu Kajita, Masaaki Hirayama, Ikuroh Ohsawa, Shigeo Ohta, Kinji Ohno

Journal:

Neuroscience Letters

Year:

2009

Language:

english

File:

PDF, 4.71 MB

english, 2009

29

Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance

Megumi Watanabe, Ken-ichiro Katsura, Ikuroh Ohsawa, Genki Mizukoshi, Kumiko Takahashi, Sadamitsu Asoh, Shigeo Ohta, Yasuo Katayama

Journal:

Year:

2008

Language:

english

File:

PDF, 563 KB

english, 2008

30

Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia–Reperfusion Injury

Oharazawa, Hideaki, Igarashi, Tsutomu, Yokota, Takashi, Fujii, Hiroaki, Suzuki, Hisaharu, Machide, Mitsuru, Takahashi, Hiroshi, Ohta, Shigeo, Ohsawa, Ikuroh

Journal:

Investigative Ophthalmology & Visual Science

Year:

2010

Language:

english

File:

PDF, 1.70 MB

english, 2010

31

Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells

Ikuroh Ohsawa, Kiyomi Nishimaki, Chie Yasuda, Kouzin Kamino, Shigeo Ohta

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 312 KB

english, 2003

32

Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index

Masaki Uematsu, Ikuroh Ohsawa, Toshiyuki Aokage, Kiyomi Nishimaki, Kouji Matsumoto, Hiroshi Takahashi, Sadamitsu Asoh, Akira Teramoto, Shigeo Ohta

Journal:

Journal of Neuro-Oncology

Year:

2005

Language:

english

File:

PDF, 455 KB

english, 2005

33

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury

Kentaro Hayashida, Motoaki Sano, Ikuroh Ohsawa, Ken Shinmura, Kayoko Tamaki, Kensuke Kimura, Jin Endo, Shigeo Ohta, Keiichi Fukuda, Satoshi Ogawa

Journal:

Journal of Cardiac Failure

Year:

2008

Language:

english

File:

PDF, 52 KB

english, 2008

34

Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor

Minoru Kogiku, Ikuroh Ohsawa, Koushi Matsumoto, Yuichi Sugisaki, Hiroshi Takahashi, Akira Teramoto, Shigeo Ohta

Journal:

Journal of Clinical Neuroscience

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

35

Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice

Nakashima, Yuya, Ohsawa, Ikuroh, Nishimaki, Kiyomi, Kumamoto, Shoichiro, Maruyama, Isao, Suzuki, Yoshihiko, Ohta, Shigeo

Journal:

BMC Complementary and Alternative Medicine

Year:

2014

Language:

english

File:

PDF, 1.00 MB

english, 2014

36

Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: On defects in the cytochrome c oxidase complex and aldehyde detoxification

Ohta, Shigeo, Ohsawa, Ikuroh, Moreira, Paula I., Oliveira, Catarina

Journal:

Journal of Alzheimer's Disease

Year:

2006

Language:

english

File:

PDF, 471 KB

english, 2006

37

Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat

Ken-ichiro Katsura, Kumiko Takahashi, Sadamitsu Asoh, Megumi Watanabe, Makoto Sakurazawa, Ikuroh Ohsawa, Takashi Mori, Hironaka Igarashi, Seiji Ohkubo, Yasuo Katayama, Shigeo Ohta

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 802 KB

english, 2008

38

The anti-cell death FNK protein protects cells from death induced by freezing and thawing

Kentaro Sudo, Sadamitsu Asoh, Ikuroh Ohsawa, Daiya Ozaki, Kumi Yamagata, Hiromoto Ito, Shigeo Ohta

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 535 KB

english, 2005

39

Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

Yoshihiko Suzuki, Motoaki Sano, Kentaro Hayashida, Ikuroh Ohsawa, Shigeo Ohta, Keiichi Fukuda

Journal:

Year:

2009

Language:

english

File:

PDF, 213 KB

english, 2009

40

Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice

Sanae Nakajima, Ikuroh Ohsawa, Shigeo Ohta, Makoto Ohno, Toshio Mikami

Journal:

Behavioural Brain Research

Year:

2010

Language:

english

File:

PDF, 753 KB

english, 2010

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